Scroll down this page to see the effects of different insulin doses and regimens on the blood glucose profile of an example insulin-dependent diabetic patient.

The first graph in the panel below shows a 24-hour blood glucose profile for a typical patient (in red). Her carbohydrate intake is shown in grams on the second graph (in green).

Blood Glucose Level (mmol/l)

The next panel below shows the patient's simulated plasma insulin level on the upper graph (in red), and her insulin regimen of Humulin S (in red) and Humulin I (in green) on the lower graph.

Plasma Insulin Level (mU/l)

This woman is on three injections of short and / or intermediate acting insulin each day, with a split-evening dose. She wants to start a family, but consistently has had quite high blood glucose levels in the early afternoon, despite numerous attempts to normalise her control in anticipation of becoming pregnant. Clearly she could decrease the amount that she eats, but this would not be ideal during pregnancy. See if you can adjust her insulin doses to improve her glycaemic control.

For example, you could try increasing the dose of the morning insulin injection(s) because of the high blood glucose level in the afternoon, or try increasing the dose of the evening insulin injection(s) because of the relatively high blood glucose level overnight. However, you will need to be careful because you do not want to send this woman low ('hypo') overnight.

Below is a data entry form showing this example patient's carbohydrate intake, insulin injection regimen, as well as other clinical variables such as weight and renal function. Try changing any of these fields to modify the regimen and click on the 'Run Simulation' button at the bottom of the page. This will result in the effects of the changes being displayed in your Web browser window.



Case Number:

Meals: Breakfast: Snack: Lunch: Snack: Supper: Snack:
Time (hhmm):
Carbohydrate (grams):

Insulin Injections:
Time (hhmm):
Short acting insulin Dose (units):
Long acting insulin Dose (units):

Kidney Function:
Renal Threshold of Glucose: Renal Function:
Insulin Sensitivities:
Liver: Peripheral:

Click on the 'Run Simulation' button above to simulate the effects of your selected changes on the example patient's blood glucose profile. Once the next set of graphs is shown you can make further changes; the number of possible simulations which can be run is nearly infinite. 39 other cases are available for interactive simulation at AIDA on-line, and you can create further cases yourself. Enjoy!

A downloadable version of the AIDA diabetes simulator for PCs (or Apple Macs running SoftWindows or VirtualPC) is also available without charge by clicking here.